Donald Bruce House, also known as Middlepen Plantation, is a historic plantation home located near Orangeburg, Orangeburg County, South Carolina. It was originally built during the 18th century in downtown Orangeburg and was moved to Middlepen Plantation about 1837. The house is a two-story frame structure with a two-tiered front piazza. It was used as headquarters during the American Revolution at different times by both Governor John Rutledge and by the British commander, Lord Francis Rawdon.